« Pharmaceutical Development

Hi,

I have put some data and references on one of my personal webpages:

http://ourworld.compuserve.com/homepages/pvosta/hcpphrm.htm

Have a look at the images and the information to nr. 17, 18, 19 and 22.

Regards and hope it is of use,

Peter

Dear Peter:

I deeply appreciate your kind introduction of your excellent paper titled "Drug Discovery and Development - Human Cytome Project" fon the web.

Although it is really a long article, I could read it extensively since the contents was so interesting.

As you wrote, the success rate of drugs falls to near 90% in these years and only 17 new drugs had been approved in the U.S. last year (50+ in several years ago).

It is really wonderful if you will put the recent success rate in each phase in the near future since we can find the data on 2004 only by web search.

 It is a bit different from the above subject, I was very much attracted by your consideration on the improvement factors of success rate. Specially, the following:

"Availability of higly reliable, highly predictive but cheap diagnostic tests." gave big impact to me.

Although this subject had been talked by many peoples for many many years, the development of drugs and diagnostics had been managed separately. Only approach to this is the recent tendency of using pharmacogenomics and phamacogenetics tests in combination with the drug(s). The issue in these cases is the deficiency in all aspects (reliability, predictivity, low cost). We should consider the importance of IVD in the process of drug development more.

I was also impressed in the Human Cytome Project too.

Thanks and regards,

Tatsuzo

Dear peter,

Thanks for a very insightful & informative article. Your article is an answer for the discussion

forum "Drug Discovery" also.

In addition to your valuable information, I'd would like to add, that all the therapies around the world should join hands together to develop new molecules. This will not only reduce the time but also cost of development.

Pl also go through this article,  which provides information about how Ayurveda & functional genomics merged together to develop new medicines & also their future implications.

 http://www.translational-medicine.com/content/6/1/14 "Merger of Ayurveda and tissue culture-based functional genomics: inspirations from systems biology".

Thanks

Devesh

Devesh… I guess you meant that Peter’s article is relevant to the topic under discussion “future of Pharma” in the Drug Discovery Forum….